We developed Polypyrrole (PPy) based NIR-photothermal related platform technologies. This photothermal driving hyperthermia carrier systems are biocompatible are able to possess versatile functions in anticancer, antibacterial, thrombolysis, wound-healingsuppression of inflammation related bioengineering potential applications. These innovative works shed light on the efficacy of combining photothermal-performance with translational manner in biomedical, clinicalindustrial designs.