Technical Name Intelligent Network-Driven Continuous Protein Purification System
Project Operator National Tsing Hua University
Project Host 黃振煌
Summary
We have combined 3D microfluidic network flow control with intelligent regulation technology to develop a continuousautomated protein purification system. It tackles the crucial purification process in biopharmaceutical production. With its compact design, intelligent operation,enclosed system, it boosts productivity, efficiency, reliability,cost-effectiveness. The integration of automatedreal-time detection ensures consistent optimal purification results.
Scientific Breakthrough
Our team develop a continuous purification system utilizes a multi-valve device to control liquid flow precisely. It reduces materialbuffer costs, as well as the carbon footprint. The system simplifies purification, reduces pipeline usage, offers disposable components, enables intelligent operation,ensures a fully enclosed setup. Validated results demonstrate its ability to continuously purify proteins, reducing purification time by 75 while maintaining purityconcentration.
Industrial Applicability
This continuous protein purification system surpasses the limitations of traditional equipment with its small size, simple operation, high reliability,cost-effectiveness. It not only achieves the desired production capacity at 1/8 of the cost of other products, but also reduces solventchromatography resin usage by 75, significantly lowering purification costsincreasing the return on investment by over 20 for businesses.
Keyword protein purification continuous purification continuous production single-use device microfluidics pharmaceutical equipment purification equipment biologics automation intelligent control
  • Contact
  • Jen-Huang Huang
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