Technical Name Method and system for monitoring and recording a viral infection process and that for screening vaccines
Project Operator National Taiwan Ocean University
Summary
The present invention relates to a detection technology, which can be used for monitoring and recording a viral infection process in host cells and that for screening effective vaccines, characterized by providing a microcantilever detection device, which comprises a microcantilever comprising a contact area having an macromolecular material attached thereon; allowing host cell to be fixed in the macromolecular material; allowing a sample containing a test virus or vaccine to be loaded into the contact area to make the test virus or vaccine to contact the host cells fixed in the macromolecular material so as to produce a deflection of the microcantilever; and recording the deflection in a time course manner so as to obtain a deflection profile that can used as a basis for determining the viral infection process or the potential efficacy of the vaccines.
Scientific Breakthrough
1. 免標定螢光或放射物質即可即時觀測。
2. 節省分析之樣本總量。
3. 了解病毒之感染過程。
4. 作為疫苗開發與篩選之檢測平台。
5. 協助藥物/保健食品/保養品效用確認。
6. 可進行批量化或陣列式生產。
Industrial Applicability
1. 醫療設備:此系統可提供廠商作為藥物/保健食品/保養品效能測試與篩選之依據與平台,目前尚未有如此低廉設備可同時具有紀錄病毒感染歷程及篩選藥物/保健食品/保養品之能力。
2 藥物研發:以完整之病毒/細菌感染歷程紀錄作為藥物/保健食品/保養品研發參考,可提升藥物/保健食品/保養品開發效率與縮短設計時間;而快速與多樣的藥物/保健食品/保養品篩選能力,亦可降低成本與加速藥物/保健食品/保養品商品化時程。且以細胞為測試對象,免除繁雜之抗體準備流程,可於一日內完成藥物/保健食品/保養品效用驗證,使廠商得以最快速度切入市場,並克服因個體差異化造成藥物/保健食品/保養品效果不一之問題。
3. 生物晶片:此生物晶片為本系統之關鍵元件,具有其特殊性與不可替代性,亦尚未出現在市場中,故可提供業者最佳之切入時機,以創造最大利潤。
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