The nanoplasmonic fiber (NPF) sensing platform system combines the localized surface plasmon resonance (LSPR) of gold nanoparticles (AuNPs) with the advantages of optical fiber. The strategy of NPF sensing is to use an incident light of narrow wavelength band for excitation of PPR and then monitoring the intensity of light exiting the fiber. Molecular binding of an analyte with a conjugated recognition molecule on the AuNP is transduced to a local increase in refractive index (RI) of the medium surrounding the AuNPs and hence an increase of plasmon absorbance of the AuNPs. In other words, when the plasmon absorbance of the AuNPs on the optical fiber increases upon molecular binding, the intensity of light exiting the fiber decreases and follows the molecular binding event in real-time. In addition, the sensing system utilizes the multiple total internal reflection (TIR) and the evanescent wave (EW) properties of optical fiber to enhance the absorption by AuNPs and significantly enhance the signal-to-noise (S/N) ratio.

此技術為光纖式定域電漿共振感測器的基本架構技術，並且整合工程技術成為全球首創之感測系統與方法。

奈米電漿子光纖生物感測器在奈米貴金屬的表面上修飾不同的辨識分子即可應用在各領域的生物檢測分析。
未來可應用的檢測領域於：
※研究用儀器 - 如生物檢測研究、藥物研發…等
※生醫檢測 - 如癌症篩檢、免疫分析、手術監控…等
※食品檢測 - 如微生物檢測、食品加工製程控管…等
※農業檢測 - 如動植物疾病、土壤及水質之生物檢測
※環境監測 - 如土地及水資源汚染物之生物檢測
※生化防護 - 如生化戰劑、病毒與細菌…等檢測