Technical Name OIL BODY CARRIERS, USES IN TARGET THERAPY AND/OR DETECTION OF THE SAME, AND FUSION PROTEINS COMPRISED THEREIN
Project Operator China Medical University
Summary
An oil body carrier, its uses in target therapy and/or detection, and a fusion protein comprised therein are provided. The oil body carrier comprises
a) the fusion protein, comprising a oil body protein and a ligand peptide, an antibody peptide, a cell penetrating peptide, or a combination thereof, and a2) a lipid,
wherein the weight/volume (μg/μl) ratio of the fusion protein and the lipid is at least about 1/25, and the average particle size of the oil body carrier is about 10 nm to about 2,000 nm.
Scientific Breakthrough
人造油體因具備相當大之外表面積,故可被利用來包覆或鑲嵌大量之生化訊號分子如量子點或螢光分子,而成為生物體內有效之光學訊號放大器,可用來追蹤並確認病灶;或可包覆非水溶性之抗癌藥物,以作為藥物投遞系統;再則,若利用油體蛋白與抗體分子融合,或與能辨識癌細胞表面受器之配體融合,人造油體便可成為帶有標靶性和訊號分子之微(奈)米球或藥物之載體。如此一來,利用油體作為抗癌制劑之載體,透過油體表面具有的配體與特定癌化細胞上的受器結合,一方面可將這些抗癌藥物投遞至癌變部位或直接作用於癌細胞,以提高區域性之藥物濃度,而不致影響正常細胞;另一方面,也可刺激癌細胞對油體藥物載體的吞噬作用與融合作用,以使得抗癌藥物專一性進入目標細胞,達到癌症治療和避免抗藥性產生之目的。
Industrial Applicability
油體、標靶藥物傳遞系統、奈米生物科技、分子影像檢測
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