Technical Name Targeting enteroviral translation machinery — novel antiviral agent and cell line for vaccine production
Project Operator Chang Gung University
Project Host 施信如
Summary
1. This technology finds that vsRNA1 can inhibit enterovirus protein synthesis. Therefore, vsRNA1 can be an enterovirus inhibitor for antiviral development. 
2. Recombinant peptides derived from FBP1 and FBP2 affect the enterovirus translation machinery. The technology utilizes recombinant polypeptides to establish vaccine cell lines to improve the virus yields required for vaccine production.
Scientific Breakthrough
1.There are no anti-viral drugs similar to vsRNA1 have been developed. 
2. Engineering host cells to establish useful vaccine cell lines, which can increase enterovirus yields for reducing the cost of vaccine production.
Industrial Applicability
Enterovirus remains an important issue for emerging viral infections worldwide. The small RNA molecule vsRNA1 will be a potential target for anti-enterovirus drug development. Moreover, the engineered cell lines can increase virus yields for vaccine production, and can be applied to virus diagnosis in clinical virology laboratory.
Keyword Enterovirus small RNA antiviral vaccine EV-A71 EV-D68 coxsackievirus FBP1 FBP2 vsRNA1
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