This technology describes a focusing ultrasound system that employs phase array driving and, with the guidance by neuronavigation, to arbitrary steer the focused ultrasound energy to transcranially deposited at the targeted brain region, to allow the enhanced large molecular penetration into the brain up to 60 folds. The developed technology provides utilization of enhanced drug delivery for indications such as brain tumor, or neuro-degenerative disease treatment.

Due to the blockage of blood-brain barrier in the brain, 98% of the therapeutic drugs cannot penetrate into the brain, which makes the treatment of brain diseases difficult. We used phase array focused ultrasound driven technology combined with surgical navigation system, precisely guided the energy to the brain target area. This technology is safe, non-invasive and able to local and temporary open BBB.

The results of the “First-in -man” clinical trial demonstrated the safety and efficiency of NaviFUS for BBB opening. As compared with the competitors, NaviFUS is low-cost, time saving, non-invasive and patient-friendly. These advantages make thi technology highly promising in industrial and clinical use.