The technology via zwitterionic-bias surface modification tech to achieve blood cell selection and capture, Through controlled the ratio of positive and negative charge functional groups, precisely controlled the degree of charge deviation within 50 nm thickness, successfully developed the method which captures leukocyte in blood.

In the blood treatment application, the relevant disclosure of charged groups although as blood treatment medium, in particular with a slightly negative charge of the surface of the filter, suitable for use for blood treatment, It does not produce allergic reactions. However, the present inventors have found the performance of the overall filter surface charge (positively charged, negatively charged or neutral) does not filter the selectivity to various factors affect blood cells, i.e. on the surface of the filter of various blood cells (positively charged, negatively charged or neutral surface) is not only of selective. Further, the above document, still using PET (polyethylene terephthalate) or the like as a porous fibrous material of the filtering medium a substrate, and then the fibrous material or the like a graft polymer surface modification treatment, to obtain a filter with a slightly negative charge surface, will not achieve the effect of an allergic reaction.
However, according to the present invention, the ionic charge-bis deviation blood cell type screening material, no fiber material such as PET for example, as a blood cell filter substrate for screening, the material itself is porous, ie autologous blood cell screening filter, nor surface modification treatment such material. However, the present invention is a double charged ion deviation blood cell type screening material may be PP (polypropylene) fibers, or the like PET fiber binding material, used as the blood cell filtering purposes.
According to a first embodiment of the present invention, discloses a dual ion charge bias blood cell type screening material, which is a copolymer of structural units and dual ion chargeable unit configured constituted, wherein diionic construction unit comprises at least one positively charged group groups to constitute one pair of a negatively charged group, the positively charged groups from the negatively charged group is a length of 1 to 5 carbon carbon bond, the charged configuration unit and the zwitterionic structural units randomly arranged ionic charge bias.

According to the present invention, the ionic charge-bis deviation blood cell type screening material, can be used as the blood cell filtering material, by means of the control of charged groups with different charges of the distance between the distribution and proportion, in line with the needs of a variety of blood cell separation. Further, according to the present invention provides a method for removing leukocytes from a blood sample, the method leukocyte removal rate greater than 95%, can achieve the purpose of efficiently removing leukocytes from a blood sample.

輸血前紅血球濃厚液減白過濾、輸血前血小板濃厚液減白過濾、輸血前全血減白過濾、血液成分分離