Microbubbles (MBs) were typically injected intravenously to improve image quality by increasing the backscattered ultrasound (US) signals as contrast agents. Recent advancements in ultrasound-mediated microbubble (US-MB) has shown that this technique can increase drug delivery efficacy and selective release of target drug. Our research team modified the MBs to carry a drug payload in their shell and extend their applications for external use. Based on this idea, we developed several experimental models for clinical therapies as follows: (1) US-aided MBs facilitate the delivery of drugs to the inner ear via the round window membrane, (2) US-MB enhanced transdermal delivery of high-molecular-weight drugs and the lightening effects of skin through modi-fication of MB sizes, (3) US-MB-based delivery system for applying minox-idil to enhance hair growth, and (4) the clinical trial of hair growth using Rogaine® (minoxidil 5%) assisted by US-MB. The application of US-MB provides a safe and more effective approach in drug delivery and its controlled release; thus, this technique holds potential for future inner ear gene delivery and gold nanoparticle-assisted drug delivery, MBs-conjugated chemotherapeu-tic medications for cancer therapy, and the development of high-efficiency transdermal drug delivery.

Microbubbles (MBs) were typically injected intravenously to improve image quality by increasing the backscattered ultrasound (US) signals as contrast agents. Recent advancements in ultrasound-mediated microbubble (US-MB) has shown that this technique can increase drug delivery efficacy and selective release of target drug. Our research team modified the MBs to carry a drug payload in their shell and extend their applications for external use. Based on this idea, we developed several experimental models for clinical therapies as follows: (1) US-aided MBs facilitate the delivery of drugs to the inner ear via the round window membrane, (2) US-MB enhanced transdermal delivery of high-molecular-weight drugs and the lightening effects of skin through modification of MB sizes, (3) US-MB-based delivery system for applying minoxidil to enhance hair growth, and (4) the clinical trial of hair growth using Rogaine® (minoxidil 5%) assisted by US-MB. The application of US-MB provides a safe and more effective approach in drug delivery and its controlled release; thus, this technique holds potential for future inner ear gene delivery and gold nanoparticle-assisted drug delivery, MBs-conjugated chemotherapeutic medications for cancer therapy, and the development of high-efficiency transdermal drug delivery.

未來臨床應用的範圍包括用於關節疼痛的外用藥物或貼布、各種經皮藥物吸收的美容美體保養成分的製劑開發，內耳藥物輸送或基因轉殖的應用，並輔以超音波能量來加強其效果。