A low-cost nanostructure-based surface plasmon resonance imaging platform, composed of a commercial transmission-type scanner, aluminum-based SPR chips and self-referenced two-color analysis, is developed for label-free and high-throughput cellular adhesion analysis. Such a portable, user-friendly, low-cost, label-free  and high-sensitivity platform can benefit to high-throughput cell biological studies, drug discovery and development and various multiplex sensing applications.

Commercial products  for label-free and high-throughput cell analysis using (1) electric cell-substrate impedance, the electric field may interfere cellular behavior; (2) The resonant waveguide grating, it requires expensive spectroscopic system.  Our technique uses a commercial scanner, nanoplasmonic chips and two-color image analysis overcome these drawbacks with  low-cost and high-sensitivity advantages .

The global label-free detection market is expected to reach USD 1,311.2 million by 2022 from USD 872.0 million in 2017, at a CAGR of 8.5%. Innovations in label-free detection technologies, increasing drug discovery programs through research partnerships between pharmaceutical companies and academic institutes, and growth in the global pharmaceutical and biotechnology industries are expected to support market growth.