The methodological procedure was developed to avoid the requirement for highly specialized medical resources and reduce time to identify the neuroanatomical location of epileptogenic zones. The co-labeling algorithm uses pre-implant magnetic resonance imaging and post-implant computed tomography fusion for the localization of epileptogenic zones and its relation with automatic labeled surrounding cortex and fiber bundle.

The technique via different universal brain atlases for localizing intracranial electrodes in an epilepsy patient, and more details for image processing are provided, particularly in localizing electrode contacts in a CT image, and in acquiring a personalized brain atlas. The technique can reconstruct a 3D model of cortical surfaces based on the registered and reoriented pre-electrode-implantation MR image.

The technique can be applied in localizing electrodes implanted intracranially, e.g., SEEG electrodes or DBS electrodes. Intracranial electrodes can be used for localizing a specific epileptic discharge site in a subject＇s brain. DBS electrodes can be used in patients requiring deep brain stimulating or requiring electrode placed in the brains, such as patients with Parkinson＇s disease, tremor, etc.