| Technical Name | Dengue and Zika virus domain III-flagellin fusion and glycan-masking E antigen for prime-boost vaccine design | ||
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| Project Operator | 生物科技所 | ||
| Project Host | 吳夙欽 | ||
| Summary | Provided is a prime-boost vaccination includes the second-dose booster of four DENV serotype and ZIKV FliC-DIII proteins to enhance the virus-neutralizing antibody titers. The invention also includes the ZIKV E protein ij loop (E-248NHT) mutation by glycan masking to reduce the elicitation of cross-reactive antibodies for DENV and ZIKV infection enhancements. |
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| Scientific Breakthrough | Provided is a prime-boost vaccination includes the second-dose booster of four DENV serotype and ZIKV FliC-DIII proteins to enhance the virus-neutralizing antibody titers. The invention also includes the ZIKV E protein ij loop (E-248NHT) mutation by glycan masking to reduce the elicitation of cross-reactive antibodies for DENV and ZIKV infection enhancements. |
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| Industrial Applicability | Our invention provides a prime-boost vaccine design including the second-dose booster of four DENV serotype and ZIKV FliC-DIII proteins to enhance the virus-neutralizing antibody titers and protection. Our invention also includes the ZIKV E protein ij loop (E-248NHT) mutation by glycan masking to reduce the elicitation of cross-reactive antibodies for DENV and ZIKV infection enhancements. |
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| Keyword | dengue virus four seotypes Zika virus vaccine flagellin E domain III prime boost immunization glycan masking cross reactive antibodies vaccine design | ||
- scwu@life.nthu.edu.tw
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