Within 10 years, Taiwan will become a super senior society with the proportions in silver hairs of more than 20. Thus, a high-throughputsmart platform with bio-physiology-marker panels is developed for PD progression by combining the bio-medicalphysical sensors, SPRsmart circuit design, leading to a new UPDRS for a more accurateearly diagnosis of a physician.

A smart sensing technology by collecting bio-physiology-markers is established to quantize the UPDRSdigitize the movement for precisely diagnosis PD stage, the progressionthe effects of medicine. In addition, a novel bio-sensing transistorSPR is applied to detect the bio-markers in plasma to achieve the early diagnosispreventive medicine for the clinical application.

The smart sensing technology can be applied for the precise medicinedigitized medicine of the early diagnosisprogression evaluation in various aging diseases such as PD, especially the technologies with IC designmanufacturing. It can be applied in IC, photonic, delicate machine, machineryfabrication, bio-technology,electronic industry, etc.